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There is no pill form. Vincristine is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. The nurse or doctor who gives Vincristine must be carefully trained. If you notice pain, redness or swelling at the IV site while you are receiving Vincristine sulfate, alert your health care professional immediately. The amount of Vincristine you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have.
Your doctor will determine your dose and schedule. Side Effects: Important things to remember about the side effects of Vincristine: Most people do not experience all of the side effects listed. Side effects are often predictable in terms of their onset and duration.
Side effects are almost always reversible and will go away after treatment is complete. There are many options to help minimize or prevent side effects. There is no relationship between the presence or severity of side effects and the effectiveness of Vincristine. Your white and red blood cells and platelets may temporarily decrease.
Onset: 7 days Nadir: days Recovery: 21 days Abdominal cramps Weight loss Nausea and vomiting Mouth sores Diarrhea Loss of appetite Taste changes Peripheral neuropathy: Although uncommon, a serious side effect of decreased sensation and paresthesia numbness and tingling of the hands and feet may be noted. Sensory loss, numbness and tingling, and difficulty in walking may last for at least as long as therapy is continued. These side effects may become progressively more severe with continued treatment, and your doctor may decide to decrease your dose.
When to contact your doctor or health care provider: Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Fever of Contact your health care provider within 24 hours of noticing any of the following: Unusual bleeding or bruising Black or tarry stools, or blood in your stools or urine Constipation Diarrhea episodes in a hour period Nausea interferes with ability to eat and unrelieved with prescribed medications Vomiting vomiting more than times in a hour period Severe abdominal pain Lip or mouth sores Painful urination Bone pain Always inform your health care provider if you experience any unusual symptoms.
Precautions: Before starting Vincristine treatment, make sure you tell your doctor about any other medications you are taking including over-the-counter, vitamins, or herbal remedies. Do not take aspirin or products containing aspirin unless your doctor permits this.
Decreased sensation, numbness and tingling in fingers and toes may become progressively worse with repeated doses of Vincristine. It is important to report this to your doctor.
Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D Vincristine may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus. For both men and women: Do not conceive a child get pregnant while taking Vincristine. Barrier methods of contraception, such as condoms, are recommended. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Do not breast feed while taking Vincristine. Self-Care Tips: Apply warm compress if you have any pain, redness or swelling at the IV site, and notify your doctor. Keep your bowels moving. Your health care provider may prescribe a stool softener to help prevent constipation that may be caused by Vincristine. Drink 2 to 3 quarts of fluid every 24 hours, unless you were told to restrict your fluid intake, and maintain good nutrition.
This will decrease your chances of being constipated, and prevent dehydration. You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your healthcare provider.
Wash your hands often. Use an electric razor and soft toothbrush to minimize bleeding. Avoid contact sports or activities that could cause injury. Avoid sun exposure. Wear SPF 15 or higher sunblock and protective clothing. To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
Keep your mouth clean with baking soda and salt rinses. In general, drinking alcoholic beverages should be minimized or avoided. You should discuss this with your doctor. If you experience symptoms or side effects, be sure to discuss them with your health care team.
Monitoring and Testing: Because drug toxicity is seen as numbness and tingling of fingers and toes, a periodic physical examination, which includes a check of your reflexes, is necessary to detect the need for decreased dosages. Periodic blood work will be obtained to monitor your complete blood count CBC.
Various blood tests to monitor the function of other organs such as your kidneys and liver will also be ordered by your doctor.
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